Helen Wheels's History
Background
Helen was actually born as a human who was taken to the Null Void by Servantis. He used Kevin's powers and a Kineceleran to create Helen's current form. She, along with Manny, Alan and Pierce formed a group, named Amalgam Kids and they were used by Servantis to do "nasty things". After they failed in their ultimate mission, their memories were completely wiped by Servantis.
Years later, Helen became part of a team of young Plumbers apprentices, the Plumbers' Helpers, which included her, Pierce and Manny. However, they had little knowledge of the technology they used, and Pierce was sucked by a Null Void Projector they had confused with a disintegrator weapon. Believing that Pierce was dead, Helen and Manny continued the work, capturing many kinds of aliens they confused for criminals and sending them into the Null Void. Though part of those they captured were DNAlien, most of them were just innocent aliens.
Alien Force
After capturing a DNAlien in Plumbers' Helpers, their alien scanner points out Ben, Gwen and Kevin Levin. Manny believes them to be aliens so he sets fire to a truck in hopes to see whether or not they are aliens. They then capture Kevin in hopes of leading Ben and Gwen to them. After a fight, Helen realizes they are not the enemy and that they have been sending the wrong aliens into the Null Void. Helen declared that she and Manny had to go into the Null Void and rescue all those who weren't meant to be in there. Manny was against the idea, until she reminds him that it was what Pierce would do.
Helen reappears alongside Pierce and Manny in Voided working with Max Tennyson trying to stop D'Void, who turns out to be Dr. Animo. She contacted Gwen to find help. Then along with the help of Ben and Max they defeat him.
In War of the Worlds: Part 2, Helen, alongside Pierce, Manny and Max help Ben defeat the Highbreed threat, once the threat is over she becomes a pupil of Max.
In Vengeance of Vilgax: Part 1, she and the other Plumbers' Helpers were defeated by Vilgax.
Helen makes another appearance in Above and Beyond (she gets attacked by Echo Echo) where Ben is supposedly attacking Max, But then it turns out to be a test and they are then told that because of their defeating Ben, as well as their heroic actions in trying to prevent the space station from hitting London, they are approved for training at the Plumbers' Academy.
Ultimate Alien
Helen was mentioned in Absolute Power: Part 1 by Alan, where he explained Ultimate Kevin stole her powers like he did to Manny, Pierce, Dr. Viktor, and Alan himself. She got her powers back after Kevin was returned to normal.
In The Ultimate Enemy: Part 2, Helen appeared in a flashback.
Omniverse
She returned in Weapon XI: Part 1, when she and Manny were on Khoros taking Gorvan into custody. However, they were attacked by Phil and Leander. Helen battled Phil but was quickly defeated, fortunately for her and Manny Ben, Gwen and Rook arrived just in time and saved them. Ben took them to Kevin's garage where Alan explained that they were used by the Rooters and had their memories wiped. When she came to the Null Void to help Kevin, she, Manny and Alan were brainwashed by Servantis and were commanded to destroy Ben. In the battle, she defeated Zed and Gwen but was quickly defeated by Alien X who was controlling Alan's body. At the end of the episode she, along with the others joined the Rooters and was commanded to hunt down Ben.
In Weapon XI: Part 2, on their search for Ben, she mentioned that she will avenge her brothers' death on Ben. Later she helped a mutated Kevin catching Ben by restraining him. Just as they were about to destroy him, Kevin grabbed Servantis, destroyed the crystal on his forehead and used Feedback's powers to free them from his control forever. Helen then hit Servantis with her tail as an act of revenge for Pierce. She and the other Amalgam kids then returned to Earth.